2023

Publications: Lista

Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension

Díaz Del Campo LS, García-Redondo AB, Rodríguez C, Zaragoza C, Duro-Sánchez S, Palmas F, de Benito-Bueno A, Socuéllamos PG, Peraza DA, Rodrigues-Díez R, Valenzuela C, Dalli J, Salaices M, Briones AM.

Hypertension. 2023 Jan;80(1):84-96. doi: 10.1161/HYPERTENSIONAHA.122.19448

2022

Publications: Lista

The Synthetic Flavonoid Hidrosmin Improves Endothelial Dysfunction and Atherosclerotic Lesions in Diabetic Mice

Jiménez-Castilla L, Opazo-Ríos L, Marin-Royo G, Orejudo M, Rodrigues-Diez R, Ballesteros-Martínez C, Soto-Catalán M, Caro-Ordieres T, Artaiz I, Suarez-Cortés T, Zazpe A, Hernández G, Cortés M, Tuñón J, Briones AM, Egido J, Gómez-Guerrero C.

Antioxidants (Basel). 2022 Dec 19;11(12):2499. doi: 10.3390/antiox11122499. PMID: 36552707; PMCID: PMC9774734.

Specialized Pro-Resolving Lipid Mediators: New Therapeutic Approaches for Vascular Remodeling

Díaz del Campo, L.S.; Rodrigues-Díez, R.; Salaices, M.; Briones, A.M.; García-Redondo, A.B.

Int. J. Mol. Sci. 2022, 23, 3592. https://doi.org/10.3390/ijms23073592

Supplementation with the Symbiotic Formulation Prodefen® Increases Neuronal Nitric Oxide Synthase and Decreases Oxidative Stress in Superior Mesenteric Artery from Spontaneously Hypertensive Rats

Méndez-Albiñana, P. Martínez-González, Á. Camacho-Rodríguez, L. Ferreira-Lazarte, Á. Villamiel, M. Rodrigues-Díez, R. Balfagón, G. García-Redondo, A.B. Prieto-Nieto, M.I. Blanco-Rivero, J

Antioxidants 2022, 11, 680. https://doi.org/10.3390/antiox11040680

CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation

Rodrigues-Díez RR, Tejera-Muñoz A, Esteban V, Steffensen LB, Rodrigues-Díez R, Orejudo M, Rayego-Mateos S, Falke LL, Cannata-Ortiz P, Ortiz A, Egido J, Mallat Z, Briones AM, Bajo MA, Goldschmeding R, Ruiz-Ortega M.

Hypertension. 2022 Mar;79(3):e42-e55. doi:10.1161/HYPERTENSIONAHA.121.18201. Epub 2021 Dec 30.

2021

Publications: Lista

Microsomal Prostaglandin E Synthase-1 (mPGES-1) is involved in the metabolic and cardiovascular alterations associated with obesity

Ballesteros-Martinez C, Rodrigues-Diez R, Beltrán LM, Moreno-Carriles R, Martínez-Martínez E, González-Amor M, Martínez-González J, Rodríguez C, Cachofeiro V, Salaices M, Briones AM

Br J Pharmacol. 2021 Dec 7. doi: 10.1111/bph.15776. Epub 2022 Feb 5. PMID: 34877656.

Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress

González-Amor M, García-Redondo AB, Jorge I, Zalba G, Becares M, Ruiz-Rodríguez MJ, Rodríguez C, Bermeo H, Rodrigues-Díez R, Rios FJ, Montezano AC, Martínez-González J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM.

Cardiovasc Res. 2021 Oct 21:cvab321. doi: 10.1093/cvr/cvab321. Online ahead of print.

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.

Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Miguel Redondo J, Mittelbrunn

M.Circulation. 2021 May 25;143(21):2091-2019.

KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in angiotensin II-induced hypertension in mice

Olivencia MA, Martínez-Casales M, Peraza DA, García-Redondo AB, Mondéjar-Parreño G, Hernanz R, Salaices M, Cogolludo A, Pennington MW, Valenzuela C, Briones AM.

Br J Pharmacol. 2021 Apr;178(8):1836-1854. doi: 10.1111/bph.15407. Epub 2021 Mar 1.

High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice.

Cañes L, Martí-Pàmies I, Ballester-Servera C, Alonso J, Serrano E, Briones AM, Rodríguez C, Martínez-González

J.Hypertension. 2021 Feb;77(2):557-570.

Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome.

Mas-Bargues C, Alique M, Barrús-Ortiz MT, Borrás C, Rodrigues-Díez R

Antioxidants (Basel). 2021 Dec 29;11(1):78. doi: 10.3390/antiox11010078.

Deletion of delta-like 1 homologue accelerates renal inflammation by modulating the Th17 immune response.

Marquez-Exposito L, Rodrigues-Diez RR, Rayego-Mateos S, Fierro-Fernandez M, Rodrigues-Diez R, Orejudo M, Santos-Sanchez L, Blanco EM, Laborda J, Mezzano S, Lamas S, Lavoz C, Ruiz-Ortega M

FASEB J. 2021 Jan;35(1):e21213. doi: 10.1096/fj.201903131R.

A Blunted Sympathetic Function and an Enhanced Nitrergic Activity Contribute to Reduce Mesenteric Resistance in Hyperthyroidism

Cros-Brunsó L, Camacho-Rodríguez L, Martínez-González Á, Llévenes P, Salaices M, García-Redondo AB, Blanco-Rivero J

Int J Mol Sci. 2021 Jan 8;22(2):570. doi: 10.3390/ijms22020570.

Chronic Low-Level Lead Exposure Increases Mesenteric Vascular Reactivity: Role of Cyclooxygenase-2-Derived Prostanoids

Simões MR, Azevedo BF, Alonso MJ, Salaices M, Vassallo DV

Front Physiol. 2021 Jan 7;11:590308. doi: 10.3389/fphys.2020.590308.

Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP

Blanco-Rivero J, Couto GK, Paula SM, Fontes MT, Rossoni LV

Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H563-H574. doi: 10.1152/ajpheart.00444.2020.

Vascular and Macrophage Heme Oxygenase-1 in Hypertension: A Mini-Review

Martínez-Casales M, Hernanz R, Alonso MJ

Front Physiol. 2021 Feb 26;12:643435. doi: 10.3389/fphys.2021.643435

Human iPSC-derived neural crest stem cells can produce EPO and induce erythropoiesis in anemic mice

Brizi V, Buttò S, Cerullo D, Michele Lavecchia A, Rodrigues-Diez R, Novelli R, Corna D, Benigni A, Remuzzi G, Xinaris C

Stem Cell Res. 2021 Aug;55:102476. doi: 10.1016/j.scr.2021.102476

Temporal relationship between systemic endothelial dysfunction and alterations in erythrocyte function in a murine model of chronic heart failure

Mohaissen T, Proniewski B, Targosz-Korecka M, Bar A, Kij A, Bulat K, Wajda A, Blat A, Matyjaszczyk-Gwarda K, Grosicki M, Tworzydlo A, Sternak M, Wojnar-Lason K, Rodrigues-Diez R, Kubisiak A, Briones A, Marzec KM, Chlopicki S

Cardiovasc Res. 2021 Oct 7:cvab306. doi: 10.1093/cvr/cvab306. Epub ahead of print

Editorial: Vascular Adjustments in Cardiovascular Disorders.

Davel AP, Blanco-Rivero J, Rossoni LV

Front Physiol. 2021 Oct 25;12:777488. doi: 10.3389/fphys.2021.777488

2020

Publications: Lista

Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation

Orejudo M, García-Redondo AB, Rodrigues-Diez RR, Rodrigues-Díez R, Santos-Sanchez L, Tejera-Muñoz A, Egido J, Selgas R, Salaices M, Briones AM, Ruiz-Ortega M

Clin Sci (Lond). 2020;134(5):513-527

Therapeutic Potential of Phosphodiesterase Inhibitors for Endothelial Dysfunction-Related Diseases

Blanco-Rivero J, Xavier FE

Curr Pharm Des. 2020;26(30):3633-3651

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities.

Pérez de Vega MJ, Moreno-Fernández S, Pontes-Quero GM, González-Amor M, Vázquez-Lasa B, Sabater-Muñoz B, Briones AM, Aguilar MR, Miguel M, González-Muñiz R.

Antioxidants (Basel). 2020 Aug 25;9(9):787.

Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction.

de Yébenes VG, Briones AM, Martos-Folgado I, Mur SM, Oller J, Bilal F, González-Amor M, Méndez-Barbero N, Silla-Castro JC, Were F, Jiménez-Borreguero LJ, Sánchez-Cabo F, Bueno H, Salaices M, Redondo JM, Ramiro AR.

Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2408-2424.

Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue.

González-Amor M, Vila-Bedmar R, Rodrigues-Díez R, Moreno-Carriles R, Arcones AC, Cruces-Sande M, Salaices M, Mayor F Jr, Briones AM, Murga C.

Antioxidants (Basel). 2020 Oct 4;9(10):953.

Hepatic Encephalopathy-Associated Cerebral Vasculopathy in Acute-on-Chronic Liver Failure: Alterations on Endothelial Factor Release and Influence on Cerebrovascular Function

Caracuel L, Sastre E, Callejo M, Rodrigues-Díez R, García-Redondo AB, Prieto I, Nieto C, Salaices M, Aller MÁ, Arias J, Blanco-Rivero J

Front Physiol. 2020;11:593371

The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock

Mendez-Barbero N, Yuste-Montalvo A, Nuñez-Borque E, Jensen BM, Gutiérrez-Muñoz C, Tome-Amat J, Garrido-Arandia M, Díaz-Perales A, Ballesteros-Martinez C, Laguna JJ, Beitia JM, Poulsen LK, Cuesta-Herranz J, Blanco-Colio LM, Esteban V

J Allergy Clin Immunol. 2020 Feb;145(2):583-596.e6. doi: 10.1016/j.jaci.2019.09.019. Epub 2019 Oct 31

Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A

Llévenes P, Rodrigues-Díez R, Cros-Brunsó L, Prieto MI, Casaní L, Balfagón G, Blanco-Rivero J

Nutrients. 2020 Jan 1;12(1):117. doi: 10.3390/nu12010117

2019

Publications: Lista

Effects of Chronic Exposure to Mercury on Angiotensin-Converting Enzyme Activity and Oxidative Stress in Normotensive and Hypertensive Rats

Vassallo DV, Simões MR, Giuberti K, Azevedo BF, Ribeiro Junior RF, Salaices M, Stefanon I.

Arq Bras Cardiol. 2019;112(4):374-380

G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases.

Murga C, Arcones AC, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr

Front Pharmacol. Section Experimental Pharmacology and Drug Discovery. 2019;10:112. REVIEW

Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite

Del Campo L, Sánchez-López A, Salaices M, von Kleeck RA, Expósito E, González-Gómez C, Cussó L, Guzmán-Martínez G, Ruiz-Cabello J, Desco M, Assoian RK, Briones AM, Andrés V

Aging Cell. 2019;18(3):e12936

Hepatic encephalopathy: Sometimes more portal than hepatic

Aller MA, Arias N, Blanco-Rivero J, Arias JL, Arias J

J Gastroenterol Hepatol. 2019; 34(3):490-494

Portal hypertension: The desperate search for the placenta

Aller MA, Arias N, Blanco-Rivero J, Balfagón G, Arias J

Curr Res Transl Med. 2019; 67(2):56-61

Wilms’ tumor 1b (wt1b) expression defines a pro-regenerative macrophage subtype and is required for organ regeneration in the zebrafish

Sanz-Morejón A, García-Redondo AB, Reuter H, Marques IJ, Bates T, Galardi-Castilla M, Große A, Manig S, Langa X, Ernst A, Piragyte I, Botos MA, González-Rosa JM, Ruiz-Ortega M, Briones AM, Salaices M, Englert C, Mercader N

Cell Reports. 2019;28(5):1296-1306.e6

Acute-on-chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries through enhanced PKA, PI3K/AKT and cGMP signalling pathways

Caracuel L, Sastre E, Llévenes P, Prieto I, Funes T, Aller MÁ, Arias J, Balfagón G, Blanco-Rivero J

Sci Rep. 2019;9(1):6993

The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension

Aller MA, Blanco-Rivero J, Arias N, Santamaria L, Arias J

Cells. 2019; 8(7):658

Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension

Orejudo M, Rodrigues-Diez RR, Rodrigues-Diez R, Garcia-Redondo A, Santos-Sánchez L, Rández-Garbayo J, Cannata-Ortiz P, Ramos AM, Ortiz A, Selgas R, Mezzano S, Lavoz C, Ruiz-Ortega M

Front Pharmacol. 2019;10:1015

Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges

Martínez-González J, Varona S, Cañes L, Galán M, Briones AM, Cachofeiro V, Rodríguez C

Biomolecules. 2019;9(10):610

Pioglitazone modulates the vascular contractility in hypertension by interference with ET-1 pathway

Palacios-Ramírez R, Hernanz R, Martín A, Pérez-Girón JV, Barrús MT, González-Carnicero Z, Aguado A, Jaisser F, Briones AM, Salaices M, Alonso MJ

Sci Rep 2019;9(1):16461

Metabolism in Acute-On-Chronic Liver Failure: The Solution More than the Problem

Aller MA, Arias N, Blanco-Rivero J, Arias J

Arch Med Res. 2019; 50(5):271-284

2018

Publications: Lista

G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis

Mayor F Jr, Cruces-Sande M, Arcones AC, Vila-Bedmar R, Briones AM, Salaices M, Murga C

Cell Signal. 2018 Jan;41:25-32. doi: 10.1016/j.cellsig.2017.04.002. Epub 2017 Apr 4.

Thyroid hormones affect nitrergic innervation function in rat mesenteric artery: Role of the PI3K/AKT pathway

Llévenes P, Balfagón G, Blanco-Rivero J

Vascul Pharmacol. 2018 Sep;108:36-45. doi: 10.1016/j.vph.2018.05.001. Epub 2018 May 8.

Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation

Rayego-Mateos S, Morgado-Pascual JL, Rodrigues-Diez RR, Rodrigues-Diez R, Falke LL, Mezzano S, Ortiz A, Egido J, Goldschmeding R, Ruiz-Ortega M

J Pathol. 2018 Feb;244(2):227-241. doi: 10.1002/path.5007. Epub 2018 Jan 10.

Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue

de Las Heras N, Klett-Mingo M, Ballesteros S, Martín-Fernández B, Escribano Ó, Blanco-Rivero J, Balfagón G, Hribal ML, Benito M, Lahera V, Gómez-Hernández A

Front Physiol. 2018 Aug 17;9:1122. doi: 10.3389/fphys.2018.01122.

Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX-2-derived prostanoids

García-Redondo AB, Esteban V, Briones AM, Díaz Del Campo LS, González-Amor M, Méndez-Barbero N, Campanero MR, Redondo JM, Salaices M

Pharmacol Res. 2018 Jul;133:236-249. doi: 10.1016/j.phrs.2018.01.001. Epub 2018 Jan 5

Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone / mineralocorticoid receptor and Rho kinase signaling

Nguyen Dinh Cat A, Callera GE, Friederich-Persson M, Sanchez A, Dulak-Lis MG, Tsiropoulou S, Montezano AC, He Y, Briones AM, Jaisser F, Touyz RM

Sci Rep. 2018;8(1):2952

mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress.

Avendaño MS, García-Redondo AB, Zalba G, González-Amor M, Aguado A, Martínez-Revelles S, Beltrán LM, Camacho M, Cachofeiro V, Alonso MJ, Salaices M, Briones AM.

Hypertension. 2018 Aug;72(2):492-502.

Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation

Zhenyukh O, González-Amor M, Rodrigues-Diez RR, Esteban V, Ruiz-Ortega M, Salaices M, Mas S, Briones AM, Egido J

J Cell Mol Med. 2018;22(10):4948-4962.

Periarterial fat from two human vascular beds is not a source of aldosterone to promote vasoconstriction

Assersen KB, Jensen PS, Briones AM, Rasmussen LM, Marcussen N, Toft A, Vanhoutte PM, Jensen BL, Hansen PBL

Am J Physiol Renal Physiol. 2018; 315(6